The roughness was correlated to the process conditions, and the resulting correlation was rigorously analyzed for the importance and co-linearities of the individual process parameters using a principal component analysis. To characterize the surface structure, the surface roughness of the coated particles was quantified using confocal laser-scanning microscopy. Spray coating experiments with Cellets ®500 particles and sodium benzoate solution were performed in a lab-scale fluidized bed varying liquid spray rate, fluidization air flow rate, fluidization air temperature, spray air temperature and spray atomization pressure. The key point in these researches is the particle design for the component particles of final dosage forms, both in the case of coarse powder particle design for formulating solid dosage forms and in the case of colloidal particle design, such as the design of liposomes for peptide drug delivery.Ī workflow for developing a multidimensional, linear correlation between the process conditions during fluidized bed spray granulation and the surface morphology of the resulting granules is presented. For example, suitable polymers were introduced for the design of specific administration routes, such as mucoadhesive liposomes for oral administration. For this purpose, we have tried to effectively use the polymer-coated liposomes in oral, pulmonary and ophthalmic administration. To design dosage forms for these APIs, novel dosage form design and administration routes are required. Another trend in recent drug therapy is an increase in the number of large bioactive molecules among the newly developed active pharmaceutical ingredients (APIs). Research on oral dosage forms, including orally disintegrating tablets (ODTs) and films (ODFs), which have recently been developed with an aim toward more patient-centric drug therapy, is also introduced. In this review, formulation research and process issues related to a popular oral dosage form, the tablet, are introduced. The most important methods will be described in detail and their fields of application (with specific examples), advantages, limitations and information about their accuracy will be given.Ī variety of dosage forms have been developed in order to achieve effective and safe drug delivery in topical or systemic drug administrations. The present paper contains a comprehensive review of the numerical simulation methods of the formation of highly ordered structured particles. porous particles have a significantly larger surface area than the simple spherical particles with similar volume. Such particles usually have very interesting features, e.g. Examples of such particles are porous particles, hollow particles (with the empty space inside), or multi-component particles with the segregation of components in the particle structure. The structured particles are the particles with well-defined topological structure. That is the reason why people are more and more interested in manufacturing structured particles. Indeed, the functionality of the nanostructure particle is defined through its application, like chromatography, sensors, microelectronics, catalysis, and others.
For these applications, the particles have to possess unique properties which arise directly from their structure and topology. They are also increasingly used in medicine (drug carriers), preparation (nanocatalysts) and many other fields. The aerosol particles play a significant role in the environment and human health. Therefore, this research has important implications for the structural design and preparation of nanocomposite particles. The novelty of this study is the analysis of the size and structure of the PLGA microparticles, which were controlled by the electrospray technique. To study the mechanism, we observed the effects of the electric voltage of the electrospray, PLGA concentration, flight distance of the droplets, and molecular weight of PLGA on the structure of the PLGA particles. When the evaporation was completed in the relatively small droplets, the microspheres with porous structures were formed in the droplets.
The structural change was related to the extent of evaporation of the solvent from the droplets during their flight. PLGA microspheres with porous structures and micro-sized nanocomposite particles comprising PLGA nanosphere aggregates were formed at 5.0–7.0kV and 2.5–3.5kV, respectively. The structure of the microspheres was controlled by changing the electric voltage of the electrospray.
Microspheres composed of poly (lactic-co-glycolic acid) (PLGA) were formed in liquid droplets using the electrospray technique.